How to Take Autophagy and Endocytosis Up a Notch | Zendy

Julia M. I. Barth | Zendy; Katja Köhler | Zendy

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How to Take Autophagy and Endocytosis Up a Notch

Author(s) -

Julia M. I. Barth,

Katja Köhler

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/960803

Subject(s) - endocytic cycle , endocytosis , autophagy , endosome , multicellular organism , microbiology and biotechnology , effector , biology , notch signaling pathway , signal transduction , cell , intracellular , genetics , apoptosis

The interconnection of the endocytic and autophagosomal trafficking routes has been recognized more than two decades ago with both pathways using a set of identical effector proteins and sharing the same ultimate lysosomal destination. More recent data sheds light onto how other pathways are intertwined into this network, and how degradation via the endosomal/autophagosomal system may affect signaling pathways in multicellular organisms. Here, we briefly review the common features of autophagy and endocytosis and discuss how other players enter this mix with particular respect to the Notch signaling pathway.

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