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This study aims to evaluate the effects of polymorphisms in glutathione (GSH-) related genes ( GSTM1 ,  GSTT1 ,  GSTP1 ,  GCLM , and  GCLC ) in the distribution of Hg in the blood compartments in humans exposed to methylmercury (MeHg). Subjects ( n  = 88), exposed to MeHg from fish consumption, were enrolled in the study. Hg species in the plasma compartment were determined by LC-ICP-MS, whereas genotyping was performed by PCR assays. Mean total Hg levels in plasma (THgP) and whole blood (THgB) were 10 ± 4.2 and 37 ± 21, whereas mean evels of plasmatic MeHg (MeHgP), inorganic Hg (IHgP), and HgP/HgB were 4.3 ± 2.9, 5.8 ± 2.3 µg/L, and 0.33 ± 0.15, respectively.  GSTM1  and  GCLC  polymorphisms influence THgP and MeHgP (multivariate analyses,  P  < 0.050). Null homozygotes for  GSTM1  showed higher THgP and MeHgP levels compared to subjects with  GSTM1  (THgP  β  = 0.22,  P  = 0.035; MeHgP  β  = 0.30,  P  = 0.050) and persons carrying at least one T allele for  GCLC  had significant higher MeHgP ( β  = 0.59,  P  = 0.046). Also, polymorphic  GCLM  subjects had lower THgP/THgB than those with the nonvariant genotype. Taken together, data of this study suggest that GSH-related polymorphisms may change the metabolism of MeHg by modifying the distribution of mercury species iin plasma compartment and the HgP/HgB partitioning.

biomed research international

Genetic Polymorphisms in Glutathione (GSH-) Related Genes Affect the Plasmatic Hg/Whole Blood Hg Partitioning and the Distribution between Inorganic and Methylmercury Levels in Plasma Collected from a Fish-Eating Population