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In previous studies, the anxiolytic-like effects of  Montanoa tomentosa  and  Montanoa frutescens  were reported in male rats, but the potential anxiolytic-like effects of  Montanoa  plants during the different phases of the ovarian cycle in rats remain to be explored. The anxiolytic-like effects of the aqueous crude extracts of  M. frutescens  (25 and 50 mg/kg) and  M. grandiflora  (25 and 50 mg/kg) in the elevated plus maze were investigated in Wistar rats during the estrous cycle and compared with 2 mg/kg diazepam as a reference anxiolytic drug. To investigate any motor effect (i.e., hyperactivity, no changes, or hypoactivity) associated with the treatments, the rats were evaluated in the open field test. The  M. frutescens  (25 and 50 mg/kg) and  M. grandiflora  (50 mg/kg) extracts exerted anxiolytic-like effects during the metestrus-diestrus phase, similar to diazepam, without disrupting spontaneous motor activity. No significant effects of the extracts were detected in either behavioral test during the proestrus-estrus phase, whereas diazepam produced motor hypoactivity in the open field test. These results indicate that the  M. frutescens  and  M. grandiflora  extracts possess anxiolytic-like effects that depend on the ovarian cycle phase, supporting the Mexican ancient medicinal use of these plants to ameliorate anxiety disorders.

biomed research international

<i>Montanoa frutescens</i>and<i>Montanoa grandiflora</i>Extracts Reduce Anxiety-Like Behavior during the Metestrus-Diestrus Phase of the Ovarian Cycle in Wistar Rats

Montanoa frutescensandMontanoa grandifloraExtracts Reduce Anxiety-Like Behavior during the Metestrus-Diestrus Phase of the Ovarian Cycle in Wistar Rats