Hepatoprotective Effect of Superfine Particles of Herbal Medicine against CCl4-Induced Acute Liver Damage in Rats | Zendy

Gang Cao | Zendy; Qinglin Li | Zendy; Xiaocheng Chen | Zendy; Hao Cai | Zendy; Sicong Tu | Zendy

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Hepatoprotective Effect of Superfine Particles of Herbal Medicine against CCl₄-Induced Acute Liver Damage in Rats

Author(s) -

Gang Cao,

Qinglin Li,

Xiaocheng Chen,

Hao Cai,

Sicong Tu

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/934732

Subject(s) - hepatoprotection , malondialdehyde , superoxide dismutase , pharmacology , alanine aminotransferase , liver damage , medicine , liver injury , chemistry , oxidative stress , biochemistry , enzyme , glutathione

This study aimed to examine the hepatoprotective effects of the superfine particles of Radix Tetrastigma (SPRT) against CCl 4 -induced acute liver damage in rats. Animals were treated with SPRT (0.3, 0.6, and 1.2 g/kg) and showed remarkable hepatoprotection against CCl 4 -induced hepatotoxicity. CCl 4 altered various biochemical parameters in rat liver, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde (MDA), superoxide dismutase (SOD), histopathological changes, and Bax and caspase-3 expressions. SPRT significantly prevented increases in ALT and AST levels, reduced MDA level, decreased Bax and caspase-3 protein expression, enhanced SOD activity, and provided significant amelioration in the histopathological lesions. These findings suggested that SPRT has significant protective effect against acute hepatotoxicity induced by CCl 4 in rats.

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