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Many naturally occurring and synthetic compounds containing dihydrocyanopyridine and cyanopyran moiety show pharmacological properties. The aim of this study is to investigate the larvicidal and antioxidant potential of dihydrophenanthroline-3-carbonitrile derivatives  4a–f . A novel series of 2-amino-10-chloro-4,12-diphenyl-1,4,5,6-tetrahydrobenzo[ j ][1,7]phenanthroline-3-carbonitrile derivatives were synthesized by reacting different substituted acridine chalcones through Michel addition. The compounds were synthesized in excellent yields and the structures were corroborated on the basis of FT-IR,  1 H NMR,  13 C NMR, and ESI Mass analysis data. All the synthesized compounds were evaluated for larvicidal activity against  Aedes aegypti  and  Culex quinquefasciatus  larvae. Furthermore, the antioxidant activity was studied by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay method. From the antioxidant assay, the compound  4c  was reported with profound antioxidant potential.

In VitroLarvicidal and Antioxidant Activity of Dihydrophenanthroline-3-carbonitriles