Open AccessThe Antiacetylcholinesterase and Antileishmanial Activities ofCanarium patentinerviumMiq.
Author(s) -
Mogana Rajagopal,
Achyut Adhikari,
Sourav Debnath,
Somnath Hazra,
Banasri Hazra,
Teng-Jin Khoo,
Christophe Wiart
Publication year - 2014
Publication title -
biomed research international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 126
eISSN - 2314-6141
pISSN - 2314-6133
DOI - 10.1155/2014/903529
Subject(s) - scopoletin , burseraceae , syringic acid , traditional medicine , chemistry , botany , umbelliferone , eriodictyol , coumarin , biology , flavonoid , antioxidant , medicine , biochemistry , gallic acid , alternative medicine , naringenin , pathology
In continuation of our natural and medicinal research programme on tropical rainforest plants, a bioassay guided fractionation of ethanolic extract of leaves of Canarium patentinervium Miq. (Burseraceae Kunth.) led to the isolation of scopoletin (1) , scoparone (2) , (+)-catechin (3) , vomifoliol (4) , lioxin (5) , and syringic acid (6) . All the compounds exhibited antiacetylcholinesterase activity with syringic acid, a phenolic acid exhibiting good AChE inhibition (IC 50 29.53 ± 0.19 μ g/mL). All compounds displayed moderate antileishmanial activity with scopoletin having the highest antileishmanial activity (IC 50 163.30 ± 0.32 μ g/mL). Given the aforementioned evidence, it is tempting to speculate that Canarium patentinervium Miq. represents an exciting scaffold from which to develop leads for treatment of neurodegenerative and parasitic diseases.
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