Nucleobase-Based Barbiturates: Their Protective Effect against DNA Damage Induced by Bleomycin-Iron, Antioxidant, and Lymphocyte Transformation Assay | Zendy

Bhaveshkumar D. Dhorajiya | Zendy; Bharatkumar Z. Dholakiya | Zendy; Ahmed S. Ibrahim | Zendy; Farid A. Badria | Zendy

Open Access

Nucleobase-Based Barbiturates: Their Protective Effect against DNA Damage Induced by Bleomycin-Iron, Antioxidant, and Lymphocyte Transformation Assay

Author(s) -

Bhaveshkumar D. Dhorajiya,

Bharatkumar Z. Dholakiya,

Ahmed S. Ibrahim,

Farid A. Badria

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/898670

Subject(s) - nucleobase , chemistry , bleomycin , antioxidant , dna damage , barbituric acid , nucleic acid , dna , abts , combinatorial chemistry , nuclear chemistry , biochemistry , biology , chemotherapy , dpph , genetics

A number of nucleobase-based barbiturates have been synthesized by combination of nucleic acid bases and heterocyclic amines and barbituric acid derivatives through green and efficient multicomponent route and one pot reaction. This approach was accomplished efficiently using aqueous medium to give the corresponding products in high yield. The newly synthesized compounds were characterized by spectral analysis (FT-IR, 1 H NMR, 13 C NMR, HMBC, and UV spectroscopy) and elemental analysis. Representative of all synthesized compounds was tested and evaluated for antioxidant, bleomycin-dependent DNA damage, and Lymphocyte Transformation studies. Compounds TBC > TBA > TBG showed highest lymphocyte transformation assay, TBC > TBA > BG showed inhibitory antioxidant activity using ABTS methods, and TBC > BPA > BAMT > TBA > 1 , 3 -TBA manifested the best protective effect against DNA damage induced by bleomycin.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research