Peptic Ulcer Diseases: Genetics, Mechanism, and Therapies

Peptic ulcer disease is a very common disease which is mainly relevant to Helicobacter pylori (H. pylori) and nonsteroid anti-inflammatory drugs (NSAIDs) [1, 2]. Recent advances in biology and medicine have introduced new technologies to study the genetics of and the mechanisms underlying its pathology. Knowledge and understanding of these conditions have led to the development of animal models, successful therapies, and novel tools to characterize these clinical conditions and provide better care to patients. In this special issue, we invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the underlying molecular issue, the development of strategies to treat these conditions, and the evaluation of outcomes. We are particularly interested in articles describing the new modalities for clinical characterization of this disease and measuring outcomes from treatment trials, advances in molecular genetics and molecular diagnostics, and current concepts in the treatment issues such as (1) recent genetic developments in peptic ulcer disease research such as genetic polymorphism and peptic ulcer disease, (2) recent advances in genetics and treatment of H. pylori, (3) latest technologies for clinical evaluation and measuring outcomes of peptic ulcer disease, (4) peptic ulcer disease mechanism using model systems such as H. pylori, (5) recent advances in peptic ulcer disease bleeding, (6) recent advances in peptic ulcer disease perforation and stenosis, and (7) recent advances in the relevant motility issue. Eventually, we published 11 papers overall.