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Background.  Blocking nitric oxide (NO) and vasodilator prostanoids (PN) does not consistently reduce flow-mediated dilation (FMD) in young adults. The impact of aging on the contribution of NO and PG to FMD is unknown.  Methods.  FMD was measured in older adults ( n  = 10, 65 ± 3 y) after arterial infusion of saline, N(G)-monomethyl-L-arginine (L-NMMA), and ketorolac + L-NMMA. Data were compared to published data in young adults.  Results.  L-NMMA reduced FMD in older adults (8.9 ± 3.6 to 5.9 ± 3.7%) although this was not statistically significant ( P  = 0.08) and did not differ ( P  = 0.74) from the reduction observed in young adults (10.0 ± 3.8 to 7.6 ± 4.7%;  P  = 0.03). Blocking PN did not affect FMD in young or older adults. In older adults, L-NMMA reduced ( n  = 6; range = 36–123% decrease), augmented ( n  = 3; 10–122% increase), or did not change FMD ( n  = 1; 0.4% increase). After PN blockade, FMD responses were reduced ( n  = 2), augmented ( n  = 6), or unaffected ( n  = 1).  Conclusions.  NO or PN blockade did not consistently reduce FMD in healthy older adults, suggesting the existence of redundant vasodilator phenotypes as observed previously in young adults.

Redundant Vasodilator Pathways Underlying Radial Artery Flow-Mediated Dilation Are Preserved in Healthy Aging