New Progress in Angiogenesis Therapy of Cardiovascular Disease by Ultrasound Targeted Microbubble Destruction | Zendy

Yangying Liao | Zendy; Zhiyi Chen | Zendy; Yì Wáng | Zendy; Yan Lin | Zendy; Feng Yang | Zendy; Qiu-Lan Zhou | Zendy

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New Progress in Angiogenesis Therapy of Cardiovascular Disease by Ultrasound Targeted Microbubble Destruction

Author(s) -

Yangying Liao,

Zhiyi Chen,

Yì Wáng,

Yan Lin,

Feng Yang,

Qiu-Lan Zhou

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/872984

Subject(s) - angiogenesis , genetic enhancement , medicine , disease , cell therapy , therapeutic angiogenesis , antiangiogenic therapy , stem cell therapy , stem cell , neovascularization , cancer research , pathology , biology , gene , mesenchymal stem cell , biochemistry , genetics

Angiogenesis plays a vital part in the pathogenesis and treatment of cardiovascular disease and has become one of the hotspots that are being discussed in the past decades. At present, the promising angiogenesis therapies are gene therapy and stem cell therapy. Besides, a series of studies have shown that the ultrasound targeted microbubble destruction (UTMD) was a novel gene delivery system, due to its advantages of noninvasiveness, low immunogenicity and toxicity, repeatability and temporal and spatial target specificity; UTMD has also been used for angiogenesis therapy of cardiovascular disease. In this review, we mainly discuss the combination of UTMD and gene therapy or stem cell therapy which is applied in angiogenesis therapy in recent researches, and outline the future challenges and good prospects of these approaches.

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