Bisphosphonate Related Osteonecrosis of the Jaw: A Study of 18 Cases Associated with Fungal Infection | Zendy

Valerie G. AFTIMOS | Zendy; Toni Zeinoun | Zendy; Rima Bou Tayeh | Zendy; Georges Aftimos | Zendy

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Bisphosphonate Related Osteonecrosis of the Jaw: A Study of 18 Cases Associated with Fungal Infection

Author(s) -

Valerie G. AFTIMOS,

Toni Zeinoun,

Rima Bou Tayeh,

Georges Aftimos

Publication year - 2014

Publication title -

international journal of dentistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.61

H-Index - 33

eISSN - 1687-8736

pISSN - 1687-8728

DOI - 10.1155/2014/869067

Subject(s) - medicine , osteonecrosis of the jaw , pathogenesis , klebsiella pneumoniae , candida albicans , bisphosphonate , microbiology and biotechnology , dermatology , pathology , biology , osteoporosis , biochemistry , escherichia coli , gene

Osteonecrosis of the jaw (ONJ) is a serious complication associated with oral and intravenous bisphosphonate therapy. Its pathogenesis is not well understood and its management is difficult. Microbiological investigations have detected a variety of oral pathogens such as Actinomyces, Enterococcus, Candida albicans , Aspergillus , Haemophilus influenzae, alpha-hemolytic streptococci, Lactobacillus, Enterobacter , and Klebsiella pneumoniae . To better treat it, it is important to understand its causes and complications. Materials and Methods . Our present study addresses a microscopic observation of curetted jaw necrotic lesions related to bisphosphonates. Results . A mycotic infestation has been found in all of the 18 cases studied. Discussion . An identification of the fungal agent and its incrimination in the pathogenesis of bisphosphonates related osteonecrosis of the jaw could change radically the management of this condition.

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