Antagonistic Interactions of “Ya-Sa-Marn-Phlae” Ethanol Extract in Combination with Topical Antiseptics against Clinical Isolates ofStaphylococcus aureus | Zendy

Sasitorn Chusri | Zendy; Sirirat Tongrod | Zendy; Julalak Chokpaisarn | Zendy; Surasak Limsuwan | Zendy; Supayang Piyawan Voravuthikunchai | Zendy

Open Access

Antagonistic Interactions of “Ya-Sa-Marn-Phlae” Ethanol Extract in Combination with Topical Antiseptics against Clinical Isolates ofStaphylococcus aureus

Author(s) -

Sasitorn Chusri,

Sirirat Tongrod,

Julalak Chokpaisarn,

Surasak Limsuwan,

Supayang Piyawan Voravuthikunchai

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/867603

Subject(s) - staphylococcus aureus , antiseptic , hydrogen peroxide , medicine , antibacterial activity , microbiology and biotechnology , methicillin resistant staphylococcus aureus , traditional medicine , chemistry , bacteria , biology , biochemistry , genetics , pathology

This investigation was aimed at assessing a possible interaction of a traditional Thai herbal recipe, “Ya-Sa-Marn-Phlae (YSMP),” used for wound treatments with topical antiseptics, povidone-iodine (PI) solution and hydrogen peroxide (H 2 O 2 ), and effects of THR-SK010 alone and the combinations on Staphylococcus aureus . Antibacterial activities of ethanol extracts from the herbal recipe were determined against both methicillin resistant Staphylococcus aureus (MRSA) and methicillin-susceptible S. aureus (MSSA). YSMP exhibited remarkable antistaphylococcal activity with MIC values of 3.9–7.8 μ g/mL. This recipe possessed bacteriostatic activity and did not reduce the tolerance of both MRSA and MSSA isolates to the high ionic strength. Interaction between THR-SK010 and the antiseptics was carried out by checkerboard testing and time-kill assay. Both indifferent and slightly antagonistic effects were observed with THR-SK010/PI and THR-SK010/H 2 O 2 combinations against the tested isolates. In addition to commercially available antiseptics, THR-SK010 offered additional therapeutic options for the decolonization of MRSA and MSSA. Topical application of plant extracts with antioxidant activity, such as THR-SK010, should not be used immediately with PI or H 2 O 2 and further investigation on this interaction is needed.

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