Microwave-Assisted Three-Component “Catalyst and Solvent-Free” Green Protocol: A Highly Efficient and Clean One-Pot Synthesis of Tetrahydrobenzo[b]pyrans | Zendy

Sougata Santra | Zendy; Matiur Rahman | Zendy; Anupam Singha Roy | Zendy; Adinath Majee | Zendy; Alakananda Hajra | Zendy

Open Access

Microwave-Assisted Three-Component “Catalyst and Solvent-Free” Green Protocol: A Highly Efficient and Clean One-Pot Synthesis of Tetrahydrobenzo[b]pyrans

Author(s) -

Sougata Santra,

Matiur Rahman,

Anupam Singha Roy,

Adinath Majee,

Alakananda Hajra

Publication year - 2014

Publication title -

organic chemistry international

Language(s) - English

Resource type - Journals

eISSN - 2090-2018

pISSN - 2090-200X

DOI - 10.1155/2014/851924

Subject(s) - malononitrile , knoevenagel condensation , chemistry , catalysis , solvent , intramolecular force , microwave irradiation , combinatorial chemistry , component (thermodynamics) , condensation , green chemistry , organic chemistry , reaction mechanism , physics , thermodynamics

A green and highly efficient method has been developed for the one-pot synthesis of tetrahydrobenzo[b]pyrans via a three-component condensation of aldehydes, 1,3-cyclic diketones, and malononitrile under MW irradiation without using any catalyst and solvent. This transformation presumably occurs by a sequential Knoevenagel condensation, Michael addition, and intramolecular cyclization. Operational simplicity, solvent and catalyst-free conditions, the compatibility with various functional groups, nonchromatographic purification technique, and high yields are the notable advantages of this procedure

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