The Trend in Distribution of Q223R Mutation of Leptin Receptor Gene in Amoebic Liver Abscess Patients from North India: A Prospective Study | Zendy

Anil Verma | Zendy; Vineet Ahuja | Zendy; Jaishree Paul | Zendy

Open Access

The Trend in Distribution of Q223R Mutation of Leptin Receptor Gene in Amoebic Liver Abscess Patients from North India: A Prospective Study

Author(s) -

Anil Verma,

Vineet Ahuja,

Jaishree Paul

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/847132

Subject(s) - gene , liver abscess , amoebic liver abscess , biology , mutation , medicine , receptor , gastroenterology , genetics , abscess

Host genetic susceptibility is an important risk factor in infectious diseases. We explored the distribution of Q223R mutation in leptin receptor gene of amoebic liver abscess (ALA) patients of North India. A total of 55 ALA samples along with 102 controls were subjected to PCR-RFLP analysis. The frequency of allele “G” (coding for arginine) was in general high in Indian population irrespective of the disease. Our results of Fisher exact test shows that heterozygous mutant (QQ versus QR, P = 0.049) and homozygous mutant (QQ versus RR, P = 0.004) were significantly associated with amoebic liver abscess when compared with homozygous wild (QQ).

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