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Objective . To investigate serum levels of free  β -HCG, progesterone, and ischemia-modified albumin (IMA) and their combined use in the prediction of first trimester abortions.  Methods . A total of 156 pregnant women between 5 and 13 weeks of gestational age were included in this study. At admission, serum levels of free  β -HCG, progesterone, and IMA were noted and all cases were divided into two groups; Group I ( n  = 77) resulted in abortion including missed abortion, incomplete/complete abortion, and inevitable abortion whereas Group II ( n  = 79) included normal pregnancies.  Results . Compared to Group II, the significantly decreased value of free  β -HCG progesterone and significantly increased value of IMA were found in Group I ( P  < 0.01,  P  < 0.01,  P  < 0.01, resp.). When combining all three parameters, sensitivity 75%, specificity 99%, PPV 98%, and NPV 76% were obtained. The multivariate logistic regression analysis revealed the free  β -HCG, progesterone, and IMA independent factors in the prediction of abortions.  Conclusions . The combined use of free  β -HCG, progesterone, and IMA levels can be useful in the prediction of first trimester spontaneous abortions.

international scholarly research notices

The Diagnostic Value of <i>β</i>-Human Chorionic Gonadotropin, Progesterone, and Ischemia-Modified Albumin and Their Combined Use in the Prediction of First Trimester Abortions

The Diagnostic Value of β-Human Chorionic Gonadotropin, Progesterone, and Ischemia-Modified Albumin and Their Combined Use in the Prediction of First Trimester Abortions