Synthetic Melatoninergic Ligands: Achievements and Prospects | Zendy

Kostiuk Nv | Zendy; M. B. Belyakova | Zendy; D. V. Leshchenko | Zendy; Veronika V. Zhigulina | Zendy; M. V. Miniaev | Zendy

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Synthetic Melatoninergic Ligands: Achievements and Prospects

Author(s) -

Kostiuk Nv,

M. B. Belyakova,

D. V. Leshchenko,

Veronika V. Zhigulina,

M. V. Miniaev

Publication year - 2014

Publication title -

isrn biochemistry

Language(s) - English

Resource type - Journals

ISSN - 2090-7729

DOI - 10.1155/2014/843478

Subject(s) - melatonin , melatonin receptor , receptor , circadian rhythm , hormone , pineal gland , biology , neuroscience , computational biology , endocrinology , biochemistry

Pineal hormone melatonin is widely used in the treatment of disorders of circadian rhythms. The presence of melatonin receptors in various animal tissues motivates the use of this hormone in some other diseases. For this reason, in recent years investigators continued the search for synthetic analogues of melatonin which are metabolically stable and selective to receptors. This review includes recent information about the most famous melatonin analogues, their structure, properties, and physiological features of the interaction with melatonin receptors.

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