31-Year-Old Female Shows Marked Improvement in Depression, Agitation, and Panic Attacks after Genetic Testing Was Used to Inform Treatment | Zendy

Scott M. Lawrence | Zendy

Open Access

31-Year-Old Female Shows Marked Improvement in Depression, Agitation, and Panic Attacks after Genetic Testing Was Used to Inform Treatment

Author(s) -

Scott M. Lawrence

Publication year - 2014

Publication title -

case reports in psychiatry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.17

H-Index - 4

eISSN - 2090-682X

pISSN - 2090-6838

DOI - 10.1155/2014/842349

Subject(s) - medicine , venlafaxine , depression (economics) , lamotrigine , panic , psychiatry , genetic testing , citalopram , pediatrics , anxiety , epilepsy , antidepressant , economics , macroeconomics

This case describes a 31-year-old female Caucasian patient with complaints of ongoing depression, agitation, and severe panic attacks. The patient was untreated until a recent unsuccessful trial of citalopram followed by venlafaxine which produced a partial response. Genetic testing was performed to assist in treatment decisions and revealed the patient to be heterozygous for polymorphisms in 5HT2C, ANK3 , and MTHFR and homozygous for a polymorphism in SLC6A4 and the low activity (Met/Met) COMT allele. In response to genetic results and clinical presentation, venlafaxine was maintained and lamotrigine was added leading to remission of agitation and depression.

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