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Nature is an unexplored reservoir of novel phytopharmaceuticals. Since biofilm-related oral diseases often correlate with antibiotic resistance, plant-derived antimicrobial agents could enhance existing treatment options. Therefore, the rationale of the present report was to examine the antimicrobial impact of Mediterranean natural extracts on oral microorganisms. Five different extracts from  Olea europaea , mastic gum, and  Inula viscosa  were tested against ten bacteria and one  Candida albicans  strain. The extraction protocols were conducted according to established experimental procedures. Two antimicrobial assays—the minimum inhibitory concentration (MIC) assay and the minimum bactericidal concentration (MBC) assay—were applied. The screened extracts were found to be active against each of the tested microorganisms.  O. europaea  presented MIC and MBC ranges of 0.07–10.00 mg mL −1  and 0.60–10.00 mg mL −1 , respectively. The mean MBC values for mastic gum and  I. viscosa  were 0.07–10.00 mg mL −1  and 0.15–10.00 mg mL −1 , respectively. Extracts were less effective against  C. albicans  and exerted bactericidal effects at a concentration range of 0.07–5.00 mg mL −1  on strict anaerobic bacteria ( Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, and Parvimonas micra ). Ethyl acetate  I. viscosa  extract and total mastic extract showed considerable antimicrobial activity against oral microorganisms and could therefore be considered as alternative natural anti-infectious agents.

High-Level Antimicrobial Efficacy of Representative Mediterranean Natural Plant Extracts against Oral Microorganisms