Benign Methodology and Efficient Catalysis for the One-Pot Multicomponent Synthesis of Dihydropyrimidinones and Thiones: A New Key for Old Lock | Zendy

Parvez Ali | Zendy; Naziyanaz B. Pathan | Zendy; Taïbi Ben Hadda | Zendy

Open Access

Benign Methodology and Efficient Catalysis for the One-Pot Multicomponent Synthesis of Dihydropyrimidinones and Thiones: A New Key for Old Lock

Author(s) -

Parvez Ali,

Naziyanaz B. Pathan,

Taïbi Ben Hadda

Publication year - 2014

Publication title -

journal of applied chemistry

Language(s) - English

Resource type - Journals

eISSN - 2314-6923

pISSN - 2356-7171

DOI - 10.1155/2014/835758

Subject(s) - biginelli reaction , ethyl acetoacetate , urea , catalysis , chemistry , combinatorial chemistry , protocol (science) , organic chemistry , lock (firearm) , reaction conditions , medicine , mechanical engineering , alternative medicine , pathology , engineering

In the present communication, under the influence of microwaves, cuprous chloride has been demonstrated to be safe, mild, efficient, and inexpensive catalyst for the Biginelli discovered multicomponent reaction (MCR) between aromatic aldehydes, urea/substituted urea, and ethyl acetoacetate to produce structurally diverse dihydropyrimidin-2(1H)-ones (DHPMs) and thiones in an ecofriendly solvent-free protocol. The practical and simple protocol led to excellent yields of the dihydropyrimidin-2(1H)-one derivatives under mild reaction conditions and within short span of reaction times with easy reaction workup by maintaining excellent atom economy

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