A Critical Role for ZDHHC2 in Metastasis and Recurrence in Human Hepatocellular Carcinoma | Zendy

Chuanhui Peng | Zendy; Zhijun Zhang | Zendy; Jian Wu | Zendy; Zhen Lv | Zendy; Jie Tang | Zendy; Haiyang Xie | Zendy; Lin Zhou | Zendy; Shusen Zheng | Zendy

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A Critical Role for ZDHHC2 in Metastasis and Recurrence in Human Hepatocellular Carcinoma

Author(s) -

Chuanhui Peng,

Zhijun Zhang,

Jian Wu,

Zhen Lv,

Jie Tang,

Haiyang Xie,

Lin Zhou,

Shusen Zheng

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/832712

Subject(s) - hepatocellular carcinoma , loss of heterozygosity , metastasis , cancer research , liver transplantation , biology , medicine , suppressor , carcinoma , pathology , oncology , transplantation , gene , cancer , genetics , allele

It has been demonstrated that loss of heterozygosity (LOH) was frequently observed on chromosomes 8p22-p23 in hepatocellular carcinoma (HCC) and was associated with metastasis and prognosis of HCC. However, putative genes functioning on this chromosomal region remain unknown. In this study, we evaluated LOH status of four genes on 8p22-p23 (MCPH1, TUSC3, KIAA1456, and ZDHHC2). LOH on ZDHHC2 was associated with early metastatic recurrence of HCC following liver transplantation and was correlated with tumor size and portal vein tumor thrombi. Furthermore, our results indicate that ZDHHC2 expression was frequently decreased in HCC. Overexpression of ZDHHC2 could inhibit proliferation, migration, and invasion of HCC cell line Bel-7402 in vitro . These results suggest an important role for ZDHHC2 as a tumor suppressor in metastasis and recurrence of HCC.

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