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We investigate game-theory based decisions on vaccination uptake and its effects on the spread of an epidemic with nonlinear incidence rate. It is assumed that each individual's decision approximates his/her best response (called smoothed best response) in that this person chooses to take the vaccine based on its cost-benefit analysis. The basic reproduction number of the resultant epidemic model is calculated and used to characterize the existence and stability of the disease-free and endemic equilibria of the model. The effects on the spread and control of the epidemic are revealed in terms of the sensitivity of the response to changes in costs and benefits, in the “cost” of the vaccination, and in the proportion of susceptible individuals who are faced with the decision of whether or not to be vaccinated per unit time. The effects of the best response decision rule are also analyzed and compared to those of the smoothed best response. Our study shows that, when there is a perceived cost to take the vaccine, the smoothed best response is more effective in controlling the epidemic. However, when this cost is 0, the best response is the more efficient control.

Disease Control through Voluntary Vaccination Decisions Based on the Smoothed Best Response