Influence of Immune Responses in Gene/Stem Cell Therapies for Muscular Dystrophies | Zendy

Andrea Farini | Zendy; Clementina Sitzia | Zendy; Silvia Erratico | Zendy; Mirella Meregalli | Zendy; Yvan Torrente | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Influence of Immune Responses in Gene/Stem Cell Therapies for Muscular Dystrophies

Author(s) -

Andrea Farini,

Clementina Sitzia,

Silvia Erratico,

Mirella Meregalli,

Yvan Torrente

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/818107

Subject(s) - immune system , sarcolemma , muscular dystrophy , inflammation , genetic enhancement , innate immune system , extracellular matrix , stem cell , gene , biology , duchenne muscular dystrophy , immunology , medicine , myocyte , microbiology and biotechnology , genetics

Muscular dystrophies (MDs) are a heterogeneous group of diseases, caused by mutations in different components of sarcolemma, extracellular matrix, or enzymes. Inflammation and innate or adaptive immune response activation are prominent features of MDs. Various therapies under development are directed toward rescuing the dystrophic muscle damage using gene transfer or cell therapy. Here we discussed current knowledge about involvement of immune system responses to experimental therapies in MDs.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research