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Peripheral giant cell granuloma (PGCG) is a relatively common benign reactive lesion of the oral cavity which can occur at any age.  CTCFL/BORIS  ( CTCF  like/Brother of the Regulator of Imprinted Sites) and  CTCF  (CCCTC-binding factor) are paralogous genes with an important role in the regulation of gene expression, genomic imprinting, and nuclear chromatin insulators regulation.  BORIS  expression promotes cell immortalization and growth while  CTCF  has tumor suppressor activity; the expression pattern may reflect the reverse transcription silencing of  BORIS . The aim of this work was to describe a histopathological and molecular approach of an 8-year-old pediatric male patient with PGCG diagnosis. It was observed that the PGCG under study expressed  CTCF  as well as  BORIS  mRNAs alongside with the housekeeping gene  GAPDH , which may be related to possible genetic and epigenetic changes in normal cells of oral cavity.

CTCFL(BORIS) mRNA Expression in a Peripheral Giant Cell Granuloma of the Oral Cavity