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One of the therapeutic approaches in treating diabetes is to reduce postprandial hyperglycemia by inhibiting major carbohydrate hydrolyzing enzymes. In the present study, crude extracts of marine seaweed,  Turbinaria ornata , were tested for their antidiabetic potential using enzyme inhibitory assays ( α -amylase,  α -glucosidase, and dipeptidyl peptidase-IV). Among the tested extracts, methanol and acetone extracts showed significant inhibitory effects on  α -amylase (IC 50  250.9  μ g/mL),  α -glucosidase (535.6  μ g/mL), and dipeptidyl peptidase-4 (55.2  μ g/mL), respectively. Free radical scavenging activity of these extracts was analyzed using DPPH assay (65%). Extracts were tested for  in vitro  toxicity using DNA fragmentation assay, haemolytic assay, and MTT assay. None of the extracts showed toxicity in tested models. Furthermore, GC-MS analysis of lead extracts showed the presence of major compounds, hentriacontane, z, z-6, 28-heptatriactontadien-2-one, 8-heptadecene, and 1-heptacosanol. Our findings suggest that  Turbinaria ornata  can be used as a potential source for further  in vivo  studies in controlling hyperglycemia.

Inhibitory Potential ofTurbinaria ornataagainst Key Metabolic Enzymes Linked to Diabetes