CXC and CC Chemokines as Angiogenic Modulators in Nonhaematological Tumors | Zendy

Matteo Santoni | Zendy; Sergio Bracarda | Zendy; Massimo Nabissi | Zendy; Francesco Massari | Zendy; Alessandro Conti | Zendy; Emilio Bria | Zendy; Giampaolo Tortora | Zendy; Giorgio Santoni | Zendy; Stefano Cascinu | Zendy

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CXC and CC Chemokines as Angiogenic Modulators in Nonhaematological Tumors

Author(s) -

Matteo Santoni,

Sergio Bracarda,

Massimo Nabissi,

Francesco Massari,

Alessandro Conti,

Emilio Bria,

Giampaolo Tortora,

Giorgio Santoni,

Stefano Cascinu

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/768758

Subject(s) - angiogenesis , chemokine , cancer research , neovascularization , inflammation , ccl7 , medicine , immunology , biology , chemokine receptor

Chemokines are a superfamily of structurally homologous heparin-binding proteins that includes potent inducers and inhibitors of angiogenesis. The imbalance between angiogenic and angiostatic chemokine activities can lead to abnormalities, such as chronic inflammation, dysplastic transformation, and even tumor development and spreading. In this review, we summarize the current literature regarding the role of chemokines as modulators of tumor angiogenesis and their potential role as therapeutic targets in patients with nonhaematological tumors.

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