Response to Rituximab in a Case of Lupus Associated Digital Ischemia | Zendy

Orhan Küçükşahin | Zendy; Nurşen Düzgün | Zendy; Alexis Okoh | Zendy; Emre Külahçıoğlu | Zendy

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Response to Rituximab in a Case of Lupus Associated Digital Ischemia

Author(s) -

Orhan Küçükşahin,

Nurşen Düzgün,

Alexis Okoh,

Emre Külahçıoğlu

Publication year - 2014

Publication title -

case reports in rheumatology

Language(s) - English

Resource type - Journals

eISSN - 2090-6889

pISSN - 2090-6897

DOI - 10.1155/2014/763608

Subject(s) - rituximab , medicine , gangrene , systemic lupus erythematosus , dermatology , ischemia , surgery , lymphoma , disease

We report the case of a 38-year-old female patient with systemic lupus erythematosus (SLE) and Jaccoud arthritis (JA) that sequentially developed digital ischemic lesions of the hands. In spite of follow-up treatment with glucocorticoids, immunosuppressant, antiaggregant, and potent vasodilatator agents, a serious progression to digital gangrene over a one-month period was observed. Surprisingly, her nonhealing digital lesions improved after two cycles of rituximab (RTX) administration.

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