The Useful Medicinal Properties of the Root-Bark Extract of Alstonia boonei (Apocynaceae) May Be Connected to Antioxidant Activity | Zendy

Miracle Oluebubechukwu Obiagwu | Zendy; Chibueze Peter Ihekwereme | Zendy; Daniel Lotanna Ajaghaku | Zendy; Festus Basden Chiedu Okoye | Zendy

Open Access

The Useful Medicinal Properties of the Root-Bark Extract of Alstonia boonei (Apocynaceae) May Be Connected to Antioxidant Activity

Author(s) -

Miracle Oluebubechukwu Obiagwu,

Chibueze Peter Ihekwereme,

Daniel Lotanna Ajaghaku,

Festus Basden Chiedu Okoye

Publication year - 2014

Publication title -

isrn pharmacology

Language(s) - English

Resource type - Journals

eISSN - 2090-5173

pISSN - 2090-5165

DOI - 10.1155/2014/741478

Subject(s) - dpph , apocynaceae , chemistry , ethyl acetate , antioxidant , bark (sound) , traditional medicine , phytochemical , ascorbic acid , organic chemistry , food science , biochemistry , biology , medicine , ecology

Folkloric use of root-bark extract of Alstonia boonei in the treatment and management of many disease conditions may be associated with free radical scavenging as part of its mechanisms of action. We therefore evaluated the ability of different solvent fractions of the methanol extract, crude precipitate from the extract, and isolated compound from the crude precipitate for scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. Phytochemical analysis revealed the presence of useful phytocompounds. Ethyl acetate fraction showed better antioxidant activity with IC 50 of 54.25 μ g/mL while acetone and methanol fractions have 121.79 and 141.67 μ g/mL, respectively. The crude precipitate and isolated compound showed IC 50 values of 364.39 and 354.94 μ g/mL, respectively. The crude precipitate, fractions, and compound 1 showed antioxidant activity against DPPH radical although lower than that of ascorbic acid.

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