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The essential oils from  Mangifera indica  var. Rosa and Espada latex were obtained by hydrodistillation and analyzed using GC-FID and GC-MS. Twenty-seven components were identified. The main compound in the essential oil from  M. indica  var. Espada (EOMiE) was terpinolene (73.6%). The essential oil of  M. indica  var. Rosa (EOMiR) was characterized by high amounts of  β -pinene (40.7%) and terpinolene (28.3%). In the test for leishmanicidal activity against promastigotes forms of  L. amazonensis , EOMiR and EOMiE showed IC 50  (72 h) of 39.1 and 23.0  μ g/mL, respectively. In macrophages, EOMiR and EOMiE showed CC 50  of 142.84 and 158.65  μ g/mL, respectively. However, both were more specific to the parasite than macrophages, with values of selectivity index of 6.91 for EOMiE and 3.66 for EOMiR. The essential oils were evaluated for their cytotoxicity against the human tumor cells HEp-2, HT-29, NCI-H292, and HL-60. The EOMiR and EOMiE were most effective against the HL-60, with IC 50  values of 12.3 and 3.6  μ g/mL, respectively. The results demonstrated that the essential oils of  M. indica  can destroy  L. amazonensis  and inhibit tumor cell growth. These findings contribute to the knowledge of the Brazilian biodiversity as a source of potential therapeutic agents.

Chemical Composition, Leishmanicidal and Cytotoxic Activities of the Essential Oils fromMangifera indicaL. var. Rosa and Espada