Design and Synthesis of Novel Isoxazole Tethered Quinone-Amino Acid Hybrids | Zendy

P. Ravi Kumar | Zendy; Manoranjan Behera | Zendy; M. Sambaiah | Zendy; Venu Kandula | Zendy; Nagaraju Payili | Zendy; Jaya Shree Anireddy | Zendy; Satyanarayana Yennam | Zendy

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Design and Synthesis of Novel Isoxazole Tethered Quinone-Amino Acid Hybrids

Author(s) -

P. Ravi Kumar,

Manoranjan Behera,

M. Sambaiah,

Venu Kandula,

Nagaraju Payili,

Jaya Shree Anireddy,

Satyanarayana Yennam

Publication year - 2014

Publication title -

journal of amino acids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.188

H-Index - 5

eISSN - 2090-0112

pISSN - 2090-0104

DOI - 10.1155/2014/721291

Subject(s) - isoxazole , quinone , cycloaddition , cerium , chemistry , bromide , alanine , yield (engineering) , combinatorial chemistry , organic chemistry , amino acid , catalysis , materials science , biochemistry , metallurgy

A new series of isoxazole tethered quinone-amino acid hybrids has been designed and synthesized involving 1,3-dipolar cycloaddition reaction followed by an oxidation reaction using cerium ammonium nitrate (CAN). Using this method, for the first time various isoxazole tethered quinone-phenyl alanine and quinone-alanine hybrids were synthesized from simple commercially available 4-bromobenzyl bromide, propargyl bromide, and 2,5-dimethoxybenzaldehyde in good yield.

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