An Improved Geometric Programming Approach for Optimization of Biochemical Systems

This paper proposes an improved geometric programming approach to address the optimization of biochemical systems. In the proposed method we take advantage of a special and interesting class of nonlinear kinetic models known as generalized massaction (GMA) models. In most situations optimization problems with GMA models are nonconvex and difficult problems to solve for global optimality. To deal with this difficulty, in this work, some transformation strategy is first used to convert the optimization problem with GMA models into an equivalent problem. Then a convexification technique is applied to transform this resulting optimization problem into a series of standard geometric programming problems that can be solved to reach a global solution. Two case studies are presented to demonstrate the advantages of the proposed method in terms of computational efficiency