SomeIn Vitro/In VivoChemically-Induced Experimental Models of Liver Oxidative Stress in Rats | Zendy

Rumyana Simeonova | Zendy; Magdalena Kondeva-Burdina | Zendy; Vessela Vitcheva | Zendy; Mitka Mitcheva | Zendy

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SomeIn Vitro/In VivoChemically-Induced Experimental Models of Liver Oxidative Stress in Rats

Author(s) -

Rumyana Simeonova,

Magdalena Kondeva-Burdina,

Vessela Vitcheva,

Mitka Mitcheva

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/706302

Subject(s) - oxidative stress , reactive oxygen species , xenobiotic , in vivo , oxidative phosphorylation , in vitro , dna damage , chemistry , oxidative damage , biochemistry , microbiology and biotechnology , pharmacology , biology , dna , enzyme , genetics

Oxidative stress is critically involved in a variety of diseases. Reactive oxygen species (ROS) are highly toxic molecules that are generated during the body's metabolic reactions and can react with and damage some cellular molecules such as lipids, proteins, or DNA. Liver is an important target of the oxidative stress because of its exposure to various prooxidant toxic compounds as well as of its metabolic function and ability to transform some xenobiotics to reactive toxic metabolites (as ROS). To investigate the processes of liver injuries and especially liver oxidative damages there are many experimental models, some of which we discuss further.

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