Lack of Association betweenTLR4Genetic Polymorphisms and Diabetic Nephropathy in a Chinese Population | Zendy

Danfeng Peng | Zendy; Jie Wang | Zendy; Jiemin Pan | Zendy; Rong Zhang | Zendy; Shanshan Tang | Zendy; Feng Jiang | Zendy; Miao Chen | Zendy; Jing Yan | Zendy; Xue Sun | Zendy; Tao Wang | Zendy; Shiyun Wang | Zendy; Yuqian Bao | Zendy; Weiping Jia | Zendy

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Lack of Association betweenTLR4Genetic Polymorphisms and Diabetic Nephropathy in a Chinese Population

Author(s) -

Danfeng Peng,

Jie Wang,

Jiemin Pan,

Rong Zhang,

Shanshan Tang,

Feng Jiang,

Miao Chen,

Jing Yan,

Xue Sun,

Tao Wang,

Shiyun Wang,

Yuqian Bao,

Weiping Jia

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/704167

Subject(s) - diabetic nephropathy , single nucleotide polymorphism , international hapmap project , haplotype , medicine , diabetes mellitus , nephropathy , immunology , tlr4 , population , biology , inflammation , genetics , endocrinology , genotype , gene , environmental health

Objective . Toll-like receptor 4 (TLR4) plays a central role in innate immunity. Activation of innate immune response and subsequent chronic low-grade inflammation are thought to be involved in the pathogenesis of diabetic nephropathy. In this study, we aimed to investigate whether TLR4 variants are associated with diabetic nephropathy in the Chinese population. Methods . Seven tagging single nucleotide polymorphisms (SNPs) of TLR4 based on HapMap Chinese data were genotyped in 1,455 Chinese type 2 diabetic patients. Of these patients, 622 were diagnosed with diabetic nephropathy and 833 were patients with diabetes for over 5 years but without diabetic nephropathy. Results . None of the SNPs and haplotypes showed significant association to diabetic nephropathy in our study. No association between the SNPs and quantitative traits was observed either. Conclusion . We concluded that common variants within TLR4 genes were not associated with diabetic nephropathy in the Chinese type 2 diabetes patients.

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