Microwave-Assisted Synthesis of Some 1,3,4-Oxadiazole Derivatives and Evaluation of Their Antibacterial and Antifungal Activity | Zendy

Deepak Swarnkar | Zendy; Rakshit Ameta | Zendy; Ritu Vyas | Zendy

Open Access

Microwave-Assisted Synthesis of Some 1,3,4-Oxadiazole Derivatives and Evaluation of Their Antibacterial and Antifungal Activity

Author(s) -

Deepak Swarnkar,

Rakshit Ameta,

Ritu Vyas

Publication year - 2014

Publication title -

organic chemistry international

Language(s) - English

Resource type - Journals

eISSN - 2090-2018

pISSN - 2090-200X

DOI - 10.1155/2014/694060

Subject(s) - chemistry , hydrazide , griseofulvin , antibacterial activity , antifungal , microwave irradiation , oxadiazole , combinatorial chemistry , carbon 13 nmr , proton nmr , organic chemistry , nuclear chemistry , bacteria , microbiology and biotechnology , catalysis , biology , medicine , pathology , genetics

A series of substituted 1,3,4-oxadiazole derivatives (3a–f) and (6a–f) have been synthesized from diphenylacetic acid hydrazide under microwave irradiation in various reaction conditions. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, and 1H NMR. These targeted compounds have been tested for their antibacterial and antifungal activities compared to ampicillin and griseofulvin as standard drug. Compounds 3a, 3e, 3f, 6c, 6d, 6e, and 6d exhibited the maximum antibacterial activities while 3b, 3c, 3d, 3e, 6a, 6d, and 6e exhibited the maximum antifungal activities

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