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The aim of the present work was to determine the  in vitro  effect of  T. vulgaris  and  O. vulgare  essential oils against  E. granulosus  protoscoleces and cysts. Essential oils were added to the medium resulting in thymol final concentrations of 10  μ g/mL. The essential oils had a time-dependent effect provoking the complete loss of protoscolex viability after 72 days of postincubation. The results were confirmed at the ultrastructure level. Loss of infectivity in protoscoleces incubated with  O. vulgare  after 60 days was observed. On the other hand, the weight of cysts recorded in mice inoculated with  T. vulgaris  treated protoscoleces was significantly lower than that obtained in control group. Gamma-glutamyl-transpeptidase activity was readily detected in the culture supernatant of protoscoleces treated either with the essential oils or thymol.  T. vulgaris  and  O. vulgare  essential oils and thymol can induce cell apoptosis of protoscoleces after short incubation times. The efficacy of  T. vulgaris  and  O. vulgare  essential oils was also demonstrated  in vitro  on  E. granulosus  murine cysts. Our data suggest that essential oils of  T. vulgaris  and  O. vulgare  have anthelmintic effect against protoscoleces and cysts of  E. granulosus .

Efficacy of Essential Oils ofThymus vulgarisandOriganum vulgareonEchinococcus granulosus