Efficacy of Essential Oils ofThymus vulgarisandOriganum vulgareonEchinococcus granulosus | Zendy

Patricia E. Pensel | Zendy; Marina A. Maggiore | Zendy; Liesel B. Gende | Zendy; Martín J. Eguaras | Zendy; M. G. Denegri | Zendy; Marı́a Celina Elissondo | Zendy

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Efficacy of Essential Oils ofThymus vulgarisandOriganum vulgareonEchinococcus granulosus

Author(s) -

Patricia E. Pensel,

Marina A. Maggiore,

Liesel B. Gende,

Martín J. Eguaras,

M. G. Denegri,

Marı́a Celina Elissondo

Publication year - 2014

Publication title -

interdisciplinary perspectives on infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.593

H-Index - 28

eISSN - 1687-7098

pISSN - 1687-708X

DOI - 10.1155/2014/693289

Subject(s) - thymol , thymus vulgaris , echinococcus granulosus , essential oil , origanum , biology , in vitro , incubation , traditional medicine , botany , microbiology and biotechnology , food science , biochemistry , medicine , ecology

The aim of the present work was to determine the in vitro effect of T. vulgaris and O. vulgare essential oils against E. granulosus protoscoleces and cysts. Essential oils were added to the medium resulting in thymol final concentrations of 10 μ g/mL. The essential oils had a time-dependent effect provoking the complete loss of protoscolex viability after 72 days of postincubation. The results were confirmed at the ultrastructure level. Loss of infectivity in protoscoleces incubated with O. vulgare after 60 days was observed. On the other hand, the weight of cysts recorded in mice inoculated with T. vulgaris treated protoscoleces was significantly lower than that obtained in control group. Gamma-glutamyl-transpeptidase activity was readily detected in the culture supernatant of protoscoleces treated either with the essential oils or thymol. T. vulgaris and O. vulgare essential oils and thymol can induce cell apoptosis of protoscoleces after short incubation times. The efficacy of T. vulgaris and O. vulgare essential oils was also demonstrated in vitro on E. granulosus murine cysts. Our data suggest that essential oils of T. vulgaris and O. vulgare have anthelmintic effect against protoscoleces and cysts of E. granulosus .

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