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Objective . This longitudinal study aims to determine if statins inhibit the response to rituximab in rheumatoid arthritis (RA) patients.   Methods . 41 patients initiating rituximab were included; 17 patients were exposed to the combination of statins and rituximab. The total cholesterol, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were assessed. The clinical response was evaluated using Disease Activity Score (DAS28) and European League against Rheumatism (EULAR) response at 6 and 18 months.  Results . A tendency of increasing in DAS28 was observed in statin-exposed group but the correlation was very weak (at 18 months:  r  = 0.013,  P  = 0.952). The statin-exposed status was negatively and very weakly correlated with EULAR response at 6 months ( r  = −0.073,  P  = 0.661) and 18 months ( r  = −0.197,  P  = 0.244). There was a negative correlation between statin-exposed status and inflammatory markers values (ESR and CRP); however, the correlation was very weak. The use of statin did not influence the cardiovascular risk measured by modified Systematic Coronary Risk Evaluation (mSCORE).  Conclusions . Long-term significant inhibitory effects of statins on rituximab treatment in RA have not been proved using clinical response scores or biologic markers.

Statins Do Not Influence Long-Term Rituximab Clinical Efficiency in Rheumatoid Arthritis Patients