The Interaction Pattern between a Homology Model of 40S Ribosomal S9 Protein ofRhizoctonia solaniand 1-Hydroxyphenaize by Docking Study | Zendy

Seema Dharni | Zendy; Sanchita Gawri | Zendy; Abdul Samad | Zendy; Ashok Sharma | Zendy; D. D. Patra | Zendy

Open Access

The Interaction Pattern between a Homology Model of 40S Ribosomal S9 Protein ofRhizoctonia solaniand 1-Hydroxyphenaize by Docking Study

Author(s) -

Seema Dharni,

Sanchita Gawri,

Abdul Samad,

Ashok Sharma,

D. D. Patra

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/682946

Subject(s) - rhizoctonia solani , docking (animal) , homology modeling , ribosomal protein , ribosomal rna , homology (biology) , microbiology and biotechnology , chemistry , biology , biochemistry , stereochemistry , ribosome , gene , enzyme , medicine , botany , rna , nursing

1-Hydroxyphenazine (1-OH-PHZ), a natural product from Pseudomonas aeruginosa strain SD12, was earlier reported to have potent antifungal activity against Rhizoctonia solani . In the present work, the antifungal activity of 1-OH-PHZ on 40S ribosomal S9 protein was validated by molecular docking approach. 1-OH-PHZ showed interaction with two polar contacts with residues, Arg69 and Phe19, which inhibits the synthesis of fungal protein. Our study reveals that 1-OH-PHZ can be a potent inhibitor of 40S ribosomal S9 protein of R. solani that may be a promising approach for the management of fungal diseases.

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