English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Vangueria madagascariensis  (VM), consumed for its sweet-sour fruits, is used as a biomedicine for the management of diabetes and bacterial infections in Africa. The study aims to assess the potential of VM on   α  -amylase,   α  -glucosidase, glucose movement, and antimicrobial activity. The antioxidant properties were determined by measuring the FRAP, iron chelating activity, and abilities to scavenge DPPH, HOCl,    ∙   OH, and NO radicals. Leaf decoction, leaf methanol, and unripe fruit methanol extracts were observed to significantly inhibit   α  -amylase. Active extracts against   α  -glucosidase were unripe fruit methanol, unripe fruit decoction, leaf decoction, and ripe fruit methanol, which were significantly lower than acarbose. Kinetic studies revealed a mixed noncompetitive type of inhibition. Leaf methanolic extract was active against  S. aureus  and  E. coli . Total phenolic content showed a strong significant positive correlation ( r  = 0.88) with FRAP. Methanolic leaf extract showed a more efficient NO scavenging potential and was significantly lower than ascorbic acid. Concerning    ∙   OH-mediated DNA degradation, only the methanol extracts of leaf, unripe fruit, and ripe fruit had IC 50  values which were significantly lower than   α  -tocopherol. Given the dearth of information on the biologic propensities of VM, this study has established valuable primary information which has opened new perspectives for further pharmacological research.

biomed research international

Biologic Propensities and Phytochemical Profile of<i>Vangueria madagascariensis</i>J. F. Gmelin (Rubiaceae): An Underutilized Native Medicinal Food Plant from Africa

Biologic Propensities and Phytochemical Profile ofVangueria madagascariensisJ. F. Gmelin (Rubiaceae): An Underutilized Native Medicinal Food Plant from Africa