Indium Titanium Oxide Nanoparticles Induced Hepatic Damage: Hepatoprotective Role of Novel 2-Imino-4-methyl-1, 2-Dihydropyrimido [5, 4C] Quinoline-5(6H)-one | Zendy

Dinesh Bheeman | Zendy; Sinjula Cheerothsahajan | Zendy; Sathish Sugumaran | Zendy; Mathan Sankaran | Zendy; Mathan Ramesh | Zendy; Sivanesan Dakshanamurthy | Zendy; Ranjithkumar Rajamani | Zendy; Chandar Shekar Bellan | Zendy

Open Access

Indium Titanium Oxide Nanoparticles Induced Hepatic Damage: Hepatoprotective Role of Novel 2-Imino-4-methyl-1, 2-Dihydropyrimido [5, 4C] Quinoline-5(6H)-one

Author(s) -

Dinesh Bheeman,

Sinjula Cheerothsahajan,

Sathish Sugumaran,

Mathan Sankaran,

Mathan Ramesh,

Sivanesan Dakshanamurthy,

Ranjithkumar Rajamani,

Chandar Shekar Bellan

Publication year - 2014

Publication title -

advances in toxicology

Language(s) - English

Resource type - Journals

eISSN - 2356-6906

pISSN - 2314-7822

DOI - 10.1155/2014/641813

Subject(s) - oxidative stress , quinoline , catalase , chemistry , glutathione , pharmacology , bilirubin , nanoparticle , biochemistry , enzyme , nanotechnology , organic chemistry , materials science , medicine

Protective role of 2-imino-4-methyl-1, 2-dihydropyrimido [5, 4C] quinoline-5(6H)-one (IMDHPQ) in indium titanium oxide nanoparticles (InTiO NPs) induced hepatotoxicity was analyzed. InTiO NPs were synthesized and given orally to albino rats to assess their hepatotoxicity. NPs mediated oxidative stress and liver tissue pathology were analyzed. Altered antioxidants (GSH, GPx, and catalase) and, biochemical (SGOT, SGPT, ALP, total protein, and total bilirubin) and histopathological changes were observed due to the oxidative stress caused by InTiO NPs. Varying effects of IMDHPQ on each parameter were observed in the present study. The altered parameters of InTiO NPs exposed rats might be due to the oxidative stress caused by NPs and hepatoprotective or ameliorative efficacy of quinoline compound IMDHPQ on signaling and molecular mechanism needs further study

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