Peripheral Leukocyte Apoptosis in Patients with Parkinsonism: Correlation with Clinical Characteristics and Neuroimaging Findings | Zendy

Wei-Che Lin | Zendy; NaiWen Tsai | Zendy; YungCheng Huang | Zendy; KueiYueh Cheng | Zendy; Hsiu-Ling Chen | Zendy; Shau-Hsuan Li | Zendy; ChiaTe Kung | Zendy; YuJih Su | Zendy; Wei-Ming Lin | Zendy; MengHsiang Chen | Zendy; Tsui-Min Chiu | Zendy; I-Hsiao Yang | Zendy; ChengHsien Lu | Zendy

Open Access

Peripheral Leukocyte Apoptosis in Patients with Parkinsonism: Correlation with Clinical Characteristics and Neuroimaging Findings

Author(s) -

Wei-Che Lin,

NaiWen Tsai,

YungCheng Huang,

KueiYueh Cheng,

Hsiu-Ling Chen,

Shau-Hsuan Li,

ChiaTe Kung,

YuJih Su,

Wei-Ming Lin,

MengHsiang Chen,

Tsui-Min Chiu,

I-Hsiao Yang,

ChengHsien Lu

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/635923

Subject(s) - neurodegeneration , parkinsonism , parkinson's disease , biomarker , disease , medicine , dopamine transporter , apoptosis , pathophysiology , peripheral , dopamine , inflammation , neuroscience , neuroimaging , immunology , pathology , oncology , bioinformatics , biology , dopaminergic , psychiatry , biochemistry

Apoptosis of both brain neurons and peripheral blood leukocyte is believed to be an important biomarker for evaluating the functional status of Parkinson's disease (PD). However, their correlation remains unknown. A better understanding of the pathophysiology of neurodegeneration is essential for the treatment and prevention of PD. The present study demonstrated that leukocyte apoptosis is significantly higher in PD patients and is associated with central dopamine neuron loss by using 99m Tc-TRODAT-1 SPECT. The leukocyte apoptosis and striatal dopamine transporter uptake ratios were further associated with increased severity and longer duration of disease. The interaction between brain and systemic inflammation may be responsible for the neurodegenerative disease progression.

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