Low Perceived Social Support Is Associated with CD8+CD57+ Lymphocyte Expansion and Increased TNF-αLevels | Zendy

Alfredo Copertaro | Zendy; Massimo Bracci | Zendy; Nicola Manzella | Zendy; Mariella Barbaresi | Zendy; Benedetta Copertaro | Zendy; Lory Santarelli | Zendy

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Low Perceived Social Support Is Associated with CD8+CD57+ Lymphocyte Expansion and Increased TNF-αLevels

Author(s) -

Alfredo Copertaro,

Massimo Bracci,

Nicola Manzella,

Mariella Barbaresi,

Benedetta Copertaro,

Lory Santarelli

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/635784

Subject(s) - immune system , confounding , lymphocyte , cd8 , social support , immunology , association (psychology) , psychology , tumor necrosis factor alpha , cytokine , medicine , clinical psychology , social psychology , psychotherapist

Social support has been supposed to have a positive impact on the function of the immune system. However, the relationship between perceived social support and immune function has not yet been fully investigated. In this cross-sectional study, we investigated the link between perceived social support and lymphocyte subpopulations and cytokines. 232 healthy subjects provided a blood sample and completed the Multidimensional Scale of Perceived Social Support (MSPSS) questionnaire. Lymphocyte immunophenotypes and cytokines were determined. Significantly increased CD8+CD57+ lymphocytes and TNF- α levels were found in group with low perceived social support. Multivariate linear regression corrected for possible confounders confirmed a significant role of perceived social support in predicting the number of CD8+CD57+ lymphocyte and TNF- α levels. This study supports the association between perceived social support and immune function. In particular, poor social support may be related to a state of chronic inflammation sustained by CD8+CD57+ lymphocyte expansion and increased TNF- α levels.

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