Gabapentin in Acute Postoperative Pain Management | Zendy

Connie Y. Chang | Zendy; Chaitanya Challa | Zendy; Janki Shah | Zendy; Jean Daniel Eloy | Zendy

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Gabapentin in Acute Postoperative Pain Management

Author(s) -

Connie Y. Chang,

Chaitanya Challa,

Janki Shah,

Jean Daniel Eloy

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/631756

Subject(s) - gabapentin , pregabalin , neuropathic pain , medicine , pharmacodynamics , anesthesia , drug , pharmacology , adverse effect , pharmacokinetics , alternative medicine , pathology

Gabapentin (1-aminomethyl-cyclohexaneacetic acid) is an amino acid that has the structure of the neurotransmitter γ -aminobutyric acid (GABA). It is a novel drug used for the treatment of postoperative pain with antihyperalgesic properties and a unique mechanism of action. Gabapentin and the related, more potent compound pregabalin have been shown to be beneficial in the treatment of neuropathic pain as well as postoperative pain following spinal surgery and hysterectomy. This study reviews five aspects of gabapentin: (1) chemical and structural characteristics; (2) pharmacokinetics and pharmacodynamics; (3) application in acute pain management; (4) adverse effects; and (5) drug safety. Overall, gabapentin has been reported to be a safe and efficacious drug for the treatment of postoperative pain.

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