Current Opportunities and Challenges of Magnetic Resonance Spectroscopy, Positron Emission Tomography, and Mass Spectrometry Imaging for Mapping Cancer MetabolismIn Vivo | Zendy

Gigin Lin | Zendy; YuenLi Chung | Zendy

Open Access

Current Opportunities and Challenges of Magnetic Resonance Spectroscopy, Positron Emission Tomography, and Mass Spectrometry Imaging for Mapping Cancer MetabolismIn Vivo

Author(s) -

Gigin Lin,

YuenLi Chung

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/625095

Subject(s) - positron emission tomography , magnetic resonance imaging , molecular imaging , cancer , preclinical imaging , in vivo , in vivo magnetic resonance spectroscopy , medicine , mass spectrometry imaging , magnetic resonance spectroscopic imaging , cancer imaging , personalized medicine , biomarker , medical physics , cancer research , nuclear medicine , bioinformatics , mass spectrometry , radiology , chemistry , biology , biochemistry , microbiology and biotechnology , chromatography

Cancer is known to have unique metabolic features such as Warburg effect. Current cancer therapy has moved forward from cytotoxic treatment to personalized, targeted therapies, with some that could lead to specific metabolic changes, potentially monitored by imaging methods. In this paper we addressed the important aspects to study cancer metabolism by using image techniques, focusing on opportunities and challenges of magnetic resonance spectroscopy (MRS), dynamic nuclear polarization (DNP)-MRS, positron emission tomography (PET), and mass spectrometry imaging (MSI) for mapping cancer metabolism. Finally, we highlighted the future possibilities of an integrated in vivo PET/MR imaging systems, together with an in situ MSI tissue analytical platform, may become the ultimate technologies for unraveling and understanding the molecular complexities in some aspects of cancer metabolism. Such comprehensive imaging investigations might provide information on pharmacometabolomics, biomarker discovery, and disease diagnosis, prognosis, and treatment response monitoring for clinical medicine.

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