Open AccessThe Antiallodynic Action of Pregabalin May Depend on the Suppression of Spinal Neuronal Hyperexcitability in Rats with Spared Nerve Injury
Author(s) -
Ding Lei,
Jie Cai,
Xiangyang Guo,
Xiu-Li Meng,
GuoGang Xing
Publication year - 2014
Publication title -
pain research and management
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.702
H-Index - 56
eISSN - 1918-1523
pISSN - 1203-6765
DOI - 10.1155/2014/623830
Subject(s) - neuropathic pain , pregabalin , medicine , nerve injury , allodynia , neuroscience , analgesic , anesthesia , neuralgia , nociception , sni , hyperalgesia , psychology , receptor , chemistry , biochemistry , hydrolysis , acid hydrolysis
Pregabalin (PGB) is a novel antiepileptic drug and is also used as a first-line medication for the treatment of neuropathic pain. However, the mechanisms of its analgesic effects remain largely unknown.
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