Open AccessCoeliac Disease
Author(s) -
Raffaella Nenna,
Stefano Guandalini,
Alina Popp,
Kalle Kurppa
Publication year - 2014
Publication title -
autoimmune diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.681
H-Index - 32
eISSN - 2090-0422
pISSN - 2090-0430
DOI - 10.1155/2014/623784
Subject(s) - gliadin , tissue transglutaminase , deamidation , disease , gluten , medicine , immunology , coeliac disease , irritable bowel syndrome , pathogenesis , t cell , human leukocyte antigen , antigen presentation , presentation (obstetrics) , epitope , antigen , immune system , pathology , biology , biochemistry , radiology , enzyme
Celiac disease is a multysystemic autoimmune disease induced by gluten in wheat, barley and rye. It is characterized by polygenic predisposition, high prevalence (1%), widely heterogeneous expression and frequent association with other autoimmune diseases, selective deficit of IgA and Down, Turner and Williams syndrome. The basis of the disease and the key finding in its diagnostics is symptomatic or asymptomatic inflammation of the small intestinal mucosa which resolves by gluten-free diet. Therefore, the basis of the treatment involves elimination diet, so that the disorder, if timely recognized and adequately treated, also characterizes excellent prognosis.
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