Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration ofRadix Salviae MiltiorrhizaeExtract, Hawthorn Extract, and a Combination of Both Extracts to Rats | Zendy

Yuqiang Liu | Zendy; Qian Cai | Zendy; Chang Liu | Zendy; Bao Fengwei | Zendy; Zhang Zhen-qiu | Zendy

Open Access

Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration ofRadix Salviae MiltiorrhizaeExtract, Hawthorn Extract, and a Combination of Both Extracts to Rats

Author(s) -

Yuqiang Liu,

Qian Cai,

Chang Liu,

Bao Fengwei,

Zhang Zhen-qiu

Publication year - 2014

Publication title -

journal of analytical methods in chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.407

H-Index - 25

eISSN - 2090-8865

pISSN - 2090-8873

DOI - 10.1155/2014/617367

Subject(s) - radix (gastropod) , rosmarinic acid , pharmacokinetics , hyperoside , pharmacology , oral administration , chemistry , chromatography , high performance liquid chromatography , traditional medicine , plasma concentration , medicine , biochemistry , rutin , biology , botany , antioxidant

A simple and sensitive HPLC method was developed for simultaneous determination of danshensu (DSS), rosmarinic acid (RA), lithospermic acid (LA), salvianolic acid B (SAB), and hyperoside (HP) in rat plasma. This method validated was successfully applied to the pharmacokinetic study of the main active ingredients after oral administration of Radix Salviae Miltiorrhizae extract (SME), hawthorn extract (HTE), and a combination of both extracts (2.5 : 1) to rats. The results indicated that there have been great differences in pharmacokinetics between a single extract and a combination of both extracts. A combination of both extracts can enhance their bioavailabilities and delay the elimination of SAB and DSS in rats.

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