Open AccessAn Efficient Method for Synthesis of N-tert-Butyl Amides Using Oxalic Acid Dihydrate in Solvent-Free Condition
Author(s) -
Masoud Mokhtary,
Seyedeh Khadijeh Nasernezhad
Publication year - 2014
Publication title -
organic chemistry international
Language(s) - English
Resource type - Journals
eISSN - 2090-2018
pISSN - 2090-200X
DOI - 10.1155/2014/617153
Subject(s) - chemistry , oxalic acid , carbocation , solvent , butanol , butyl acetate , organic chemistry , medicinal chemistry , ethanol
An efficient method for the synthesis of N-tert-butyl amides by reaction of nitriles with tert-butyl acetate or tert-butanol is described using oxalic acid dihydrate in solvent-free condition. The result showed that tert-butyl acetate served as a relatively better source of tert-butyl carbocation than tert-butanol
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