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Vibrio cholerae , the causative agent of the diarrhoeal disease cholera, survives in aquatic environments. The bacterium has developed a survival strategy to grow and survive inside  Acanthamoeba castellanii . It has been shown that  V. cholerae  expresses outer membrane proteins as virulence factors playing a role in the adherence to interacted host cells. This study examined the role of outer membrane protein A (OmpA) and outer membrane vesicles (OMVs) in survival of  V. cholerae  alone and during its interaction with  A. castellanii . The results showed that an  OmpA  mutant of  V. cholerae  survived longer than wild-type  V. cholerae  when cultivated alone. Cocultivation with  A. castellanii  enhanced the survival of both bacterial strains and  OmpA  protein exhibited no effect on attachment, engulfment, and survival inside the amoebae. However, cocultivation of the  OmpA  mutant of  V. cholerae  decreased the viability of  A. castellanii  and this bacterial strain released more OMVs than wild-type  V. cholerae . Surprisingly, treatment of amoeba cells with OMVs isolated from the  OmpA  mutant significantly decreased viable counts of the amoeba cells. In conclusion, the results might highlight a regulating rule for  OmpA  in survival of  V. cholerae  and OMVs as a potent virulence factor for this bacterium towards eukaryotes in the environment.

international journal of microbiology

Lack of Outer Membrane Protein A Enhances the Release of Outer Membrane Vesicles and Survival of<i>Vibrio cholerae</i>and Suppresses Viability of<i>Acanthamoeba castellanii</i>

Lack of Outer Membrane Protein A Enhances the Release of Outer Membrane Vesicles and Survival ofVibrio choleraeand Suppresses Viability ofAcanthamoeba castellanii