Osteoblast-Like Cell Behavior on Porous Scaffolds Based on Poly(styrene) Fibers | Zendy

Andrada Serafim | Zendy; Romain Mallet | Zendy; Florence PascarettiGrizon | Zendy; IzabelaCristina Stancu | Zendy; Daniel Chappard | Zendy

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Osteoblast-Like Cell Behavior on Porous Scaffolds Based on Poly(styrene) Fibers

Author(s) -

Andrada Serafim,

Romain Mallet,

Florence PascarettiGrizon,

IzabelaCristina Stancu,

Daniel Chappard

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/609319

Subject(s) - materials science , osteoblast , microfiber , scanning electron microscope , porosity , biomedical engineering , surface roughness , scaffold , nanotechnology , composite material , chemistry , in vitro , medicine , biochemistry

Scaffolds of nonresorbable biomaterials can represent an interesting alternative for replacing large bone defects in some particular clinical cases with massive bone loss. Poly(styrene) microfibers were prepared by a dry spinning method. They were partially melted to provide 3D porous scaffolds. The quality of the material was assessed by Raman spectroscopy. Surface roughness was determined by atomic force microscopy and vertical interference microscopy. Saos-2 osteoblast-like cells were seeded on the surface of the fibers and left to proliferate. Cell morphology, evaluated by scanning electron microscopy, revealed that they can spread and elongate on the rough microfiber surface. Porous 3D scaffolds made of nonresorbable poly(styrene) fibers are cytocompatible biomaterials mimicking allogenic bone trabeculae and allowing the growth and development of osteoblast-like cells in vitro .

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