Open AccessUVA-UVB Photoprotective Activity of Topical Formulations ContainingMorinda citrifoliaExtract
Author(s) -
Mairim Russo Serafini,
Cássia Britto Detoni,
Paula dos Passos Menezes,
Rose Nely Pereira Filho,
Vanessa Silveira Fortes,
Maria José Fonseca Vieira,
Sı́lvia Stanisçuaski Guterres,
Ricardo Luiz Cavalcanti de Albuquerque Júnior,
Adriano Antunes de Souza Araújo
Publication year - 2014
Publication title -
biomed research international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 126
eISSN - 2314-6141
pISSN - 2314-6133
DOI - 10.1155/2014/587819
Subject(s) - sunburn , photoaging , morinda , dermatology , erythema , photoprotection , human skin , medicine , chemistry , skin cancer , traditional medicine , biology , biochemistry , photosynthesis , genetics , cancer
Exposure to solar radiation, particularly its ultraviolet (UV) component, has a variety of harmful effects on human health. Some of these effects include sunburn cell formations, basal and squamous cell cancers, melanoma, cataracts, photoaging of the skin, and immune suppression. The beneficial photoprotective effects of topical formulations with the extract, Morinda citrifolia , have not been investigated. This present study aims to investigate the potential benefits of M. citrifolia topical application on the dorsal skin of mice, exposed to UVA-UVB light. Using 7 days of treatment, [before (baseline values) and 20 h after UV exposure], the thickness, skin barrier damage (TEWL), erythema, and histological alterations were evaluated. The results showed that the formulations containing the extract protected the skin against UV-induced damage.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom