Role of IL-33 and Its Receptor in T Cell-Mediated Autoimmune Diseases | Zendy

Qing Zhao | Zendy; Guangjie Chen | Zendy

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Role of IL-33 and Its Receptor in T Cell-Mediated Autoimmune Diseases

Author(s) -

Qing Zhao,

Guangjie Chen

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/587376

Subject(s) - immunology , interleukin 33 , immune system , receptor , biology , cytokine , autoimmune disease , inflammation , interleukin , medicine , antibody , genetics

Interleukin-33 (IL-33) is a new cytokine of interleukin-1 family, whose specific receptor is ST2. IL-33 exerts its functions via its target cells and plays different roles in diseases. ST2 deletion and exclusion of IL-33/ST2 axis are accompanied by enhanced susceptibility to dominantly T cell-mediated organ-specific autoimmune diseases. It has been reported that IL-33/ST2 pathway plays a key role in host defense and immune regulation in inflammatory and infectious diseases. This review focuses on new findings in the roles of IL-33 and ST2 in several kinds of T cell-mediated autoimmune diseases.

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